Recent Posts
- MicroRNA-Mediated Metastasis Suppression
- A New Explanation Of ‘Asian Paradox’
- Toward Bold New Anti-cancer Medicines
- Celsion And Yakult Honsha Announce Treatment Of First Patient In Japan In Celsion’s Global Phase III ThermoDox(R) Trial For Primary Liver Cancer
- $6.5 Million Gift To UCSF From Irwin And Joan Jacobs For Head And Neck Cancer Research
| M | T | W | T | F | S | S |
|---|---|---|---|---|---|---|
| « Nov | ||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| 15 | 16 | 17 | 18 | 19 | 20 | 21 |
| 22 | 23 | 24 | 25 | 26 | 27 | 28 |
| 29 | 30 | 31 | ||||
Random Posts
- ASCO: Earlier Treatment Fails to Improve Survival in Ovarian Cancer
- ASCO: Fertility Preservation Not a Top Priority for Oncologists
- Radiotherapy Could Reduce Cognitive Function In Patients With Common Brain Tumours
- ECCO-ESMO: Personalized Radiotherapy Takes a Step Forward
- DDW: Spit Test for Pancreatic Cancer a Possibility (CME/CE)
- Purdue Researchers Create Prostate Cancer 'Homing Device' For Drug Delivery
- Varian Introduces Brachytherapy Applicator Set To Optimize Precision And Comfort Of Bronchial Cancer Treatments
- Low-Fat Diet Helps Genetically Predisposed Animals Avoid Liver Cancer
- Agios Pharmaceuticals Highlights Extensive Cancer Metabolism Research At AACR
- Technique Eradicates Problems In Most Patients With Barrett's Esophagus
Prescription Cancer Drugs
A New Explanation Of ‘Asian Paradox’
Posted by: admin in Prescription Cancer Drugs on November 08th, 2009
Although Helicobacter pylori (H. pylori) has been classified as a class I (or definite) carcinogen by World Health Organization (WHO), the controversy as to why only a minority of infected patients develop gastric cancer still remains. Moreover, in Asian countries such as Indonesia, Japan, China, and Thailand, where the H. pylori infection rates are similar, there is a significant difference regarding the outcome of gastric cancer. That fact has been termed the “Asian paradox”.
A research article published in the World Journal of Gastroenterology addresses this question. Research, led by Murdani Abdullah, MD from Division of Gastroenterology, Department of Internal Medicine, University of Indonesia, was based on the old concept of a cascade of mucosal changes that develops from acute/chronic gastritis to gastric cancer as proposed by P. Correa. The difference in the pattern of H. pylori-associated gastritis may explain the difference in the incidence of gastric cancer between Indonesia and Japan. Previous studies have never evaluated the cascade of gastric mucosal changes prior to gastric cancer. In this research, the transformation of gastric mucosa that is induced by H. pylori infection prior to gastric cancer was investigated. The transformation was then compared between Indonesian and Japanese patients, the two countries that represent the “Asian paradox”.
From 1998 to 1999, 42 Japanese patients at Yamanashi Medical University Hospital, Koufu and 125 Indonesian patients at Metropolitan Medical Centre Hospital, Jakarta were consecutively enrolled. From this research, it was seen that there was a significant difference in the grade and activity of gastric mucosal changes between Indonesian and Japanese H. pylori-positive patients. This finding suggests that there may be a different host response between Indonesian and Japanese people regarding H. pylori infection. The authors believe that lifestyle and genetic factors are considered to play a major role, in the meantime, their research may act as the initial step in explaining the “Asian paradox”.
Reference: Abdullah M, Ohtsuka H, Rani AA, Sato T, Syam AF, Fujino MA. Helicobacter pylori infection and gastropathy: A comparison between Indonesian and Japanese patients. World J Gastroenterol 2009; 15(39): 4928-4931 http://www.wjgnet.com/1007-9327/15/4928.asp
Source: Jin-Lei Wang
World Journal of Gastroenterology