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Prescription Cancer Drugs
Gallbladder Polyps And Endoscopic Ultrasonography
Posted by: admin in Prescription Cancer Drugs on June 12th, 2009
Although most gallbladder (GB) polyps are benign, some early carcinomas of the GB share the same appearance as benign polyps. Currently, GB polyps larger than 1 cm should be surgically removed because of the increased risk of malignancy. On the other hand, patients with smaller polyps usually require repeated US and follow-up. Distinguishing among non-neoplastic, neoplastic, and potentially malignant lesions is a major diagnostic dilemma, and the therapeutic options for these lesions remain controversial.
A research article published in the World Journal of Gastroenterology addresses this problem.
EUS is considered to be superior to conventional US for imaging GB lesions, because EUS can provide high-resolution images of small lesions at higher ultrasound frequencies (7.5-12 MHZ vs 3.5-5 MHz). Many studies have investigated the relationship between the neoplastic nature of GB polyps and their morphological characteristics such as the number of polyps, the polyp shape, the diameter of the largest polyp, the echo level and internal echo pattern, and the polyp margin. Among these variables, size is the most significant predictor of neoplastic polyps.
EUS could not differentiate malignant lesions from benign polyps less than 1.0 cm in size, because such small polyps do not often show findings typical of cholesterol polyps, localized types of adenomyomatosis, or neoplastic lesions. Thus, EUS alone is not sufficient for determining a treatment strategy for benign polypoid lesion of less than 1.0 cm.
Reference: Cheon YK, Cho WY, Lee TH, Cho YD, Moon JH, Lee JS, Shim CS. Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps. World J Gastroenterol 2009; 15(19): 2361-2366
Correspondence to: Dr. Young Koog Cheon, Institute for Digestive Research and Digestive Disease Center, Soon Chun Hyang University College of Medicine, 657 Hannam-Dong, Yongsan-Ku, Seoul 140-743, South Korea.
Source:
Jian-Xia Cheng
World Journal of Gastroenterology
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